Linking How Horses Run to Their Alleles
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A paper in PLoS Genetics has identified a selection of genetic variants that clearly distinguish horses breeds that pace (running with the two legs on the same side move together) and those that trot (opposite front and back move together). Thought no physiological role has been demonstrated for the these mutations, yet, they appear to be good candidates for connecting single nucleotide changes to discrete and clearly recognizable inherited differences in behavior—and maybe a step towards understanding instincts.
McCoy, et al. (2019) Identification and validation of genetic variants predictive of gait in standardbred horses. PLoS Genetics
Author summary
Certain horse breeds have been developed over generations specifically for the ability to perform alternative patterns of movement, or gaits. Current understanding of the genetic basis for these gaits is limited to one known mutation apparently necessary, but not sufficient, for explaining variability in “gaitedness.” The Standardbred breed includes two distinct groups, trotters, which exhibit a two-beat gait in which the opposite forelimb and hind limb move together, and pacers, which exhibit an alternative two-beat gait where the legs on the same side of the body move together. Our long-term objective is to identify variants underlying the ability of certain Standardbreds to pace. In this study, we were able to identify several regions of the genome highly associated with pacing and, within these regions, a number of specific highly associated variants. Although the biological function of these variants has yet to be determined, we developed a model based on seven variants that was > 99% accurate in predicting whether an individual was a pacer or a trotter in two independent populations. This predictive model can be used by horse owners to make breeding and training decisions related to this economically important trait, and by scientists interested in understanding the biology of coordinated gait development.
